What is it about?
In general, brain is protected from blood antibodies by blood-brain barriers. We surprisingly found that presence of blood circulating antibodies against NMDAR1, a brain-specific protein essential for cognitive functions, is sufficient to impair cognitive performance in healthy mice.
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Why is it important?
Antibodies last months and years in human blood. ~5-10% of the general human population have some levels of blood antibodies against NMDAR1. Will these antibodies impact human cognitive functions and/or contribute to psychiatric symptoms?
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This page is a summary of: Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice, PLoS ONE, September 2021, PLOS, DOI: 10.1371/journal.pone.0256972.
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