What is it about?
Nampula province has poor health indicators including a high burden of Rotavirus infection and circulation of uncommon genotypes. We described the frequency, risk factors; genotype distribution by vaccination status, and age between pre- and post-vaccine periods in children under-five years old with diarrhea in Nampula
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Why is it important?
The present analysis showed that Rotavirus A infection reduced slightly in the post-vaccine period, with a high proportion of infection and genotype diversity in children, under 12 months of age, vaccinated. Further research on factors associated with RVA infection on vaccinated compared to unvaccinated children and vaccination optimization should be done.
Perspectives
This article shows different challenges existing in a poor setting to reduce the burden of Rotavirus infection. To achieve children's protection vaccination is not sufficient, combined action such as nutrition, water sanitation, and hygiene are needed. This article also open future research lines in Mozambique in order to understand the Rotavirus epidemiology such as: (i) the reason why vaccinated children are infected with RVA to the point of requiring hospitalization; (ii) the role of animals in the occurrence of new/uncommon RVA genotypes to optimize the vaccination.
Assucênio Chissaque
Instituto Nacional de Saúde - Moçambique
Read the Original
This page is a summary of: Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019), PLoS ONE, August 2021, PLOS,
DOI: 10.1371/journal.pone.0255720.
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