What is it about?

Phenylethyl isothiocyanate (PEITC) is a potent compound with exciting potential for health benefits. However, it faces challenges in being effectively utilized due to its low stability and limited ability to dissolve in water. We have improved a commonly used solution to overcome these obstacles: tiny particles called microparticles. These microparticles act as protective capsules for PEITC, enhancing its solubility and preserving its beneficial properties. Through careful experimentation, we have identified the optimal combination of ingredients—chitosan and olive oil—to create these microparticles. The result is a remarkable formulation that significantly improves the delivery of PEITC. This breakthrough opens up exciting possibilities for using PEITC in biomedical, nutraceutical, and food applications. By encapsulating PEITC in these specially designed microparticles, we are unlocking its full potential to benefit human health and well-being.

Featured Image

Why is it important?

This article represents a significant advancement in the field of bioactive compound delivery systems. What makes this work unique is the successful development of microparticles that encapsulate and protect PEITC, thereby addressing its stability and solubility challenges. This breakthrough is timely, aligning with the increasing interest in natural compounds and their potential health benefits.


This is my first published article on the design of microparticles for the delivery of bioactive compounds oriented to the gastrointestinal system's health, a field I have been deepening in recent years. The importance of this work lies in its potential to improve human health and well-being. By increasing the bioavailability and stability of PEITC, these microparticles offer a more efficient and reliable way to harness the therapeutic properties of this natural compound. Ultimately, this work has the potential to inspire further research, innovation, and the development of novel applications for PEITC and other bioactive compounds.

Dr. Ezequiel Coscueta
Universidade Catolica Portuguesa

Read the Original

This page is a summary of: Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: Optimal formulation, PLoS ONE, May 2021, PLOS, DOI: 10.1371/journal.pone.0248257.
You can read the full text:



The following have contributed to this page