What is it about?

MicroRNAs (miRNAs) small non-coding RNAs 18–23 nucleotides in length, and play a critical role in multiple aspects of biology via repression of specific gene expression. We have identified testicular germ cell-specific miRNAs, and they play a crucial role in proliferation and differentiation of sperm stem cells via repression of a specific signaling pathway.

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Why is it important?

Sperm stem cells, namely spermatogonia ensure continuous sperm production throughout ones’ life of males. Our study shows an important molecular basis for life-long stable sperm production, by which animals including human enable to prosper their descendants.

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This page is a summary of: Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions, PLoS ONE, February 2019, PLOS, DOI: 10.1371/journal.pone.0211739.
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