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This study shows that gamma retroviral integration is more selective than previously imagined. This helps explain the high oncogenic potency of these viruses in nature and the problem of vector-induced leukemias in human gene therapy trials. It also offers a novel approach to identify driver genes in human cancer cells.
Prof James C Neil
University of Glasgow
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This page is a summary of: Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics, PLOS One, April 2016, PLOS,
DOI: 10.1371/journal.pone.0154070.
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