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Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics
Kathryn L. Gilroy, Anne Terry, Asif Naseer, Jeroen de Ridder, Amin Allahyar, Weiwei Wang, Eric Carpenter, Andrew Mason, Gane K-S. Wong, Ewan R. Cameron, Anna Kilbey, James C. Neil
PLoS ONE, April 2016, Public Library of Science (PLoS)
Gamma retroviruses preferentially integrate near cancer genes
Prof James C Neil
University of Glasgow
This study shows that gamma retroviral integration is more selective than previously imagined. This helps explain the high oncogenic potency of these viruses in nature and the problem of vector-induced leukemias in human gene therapy trials. It also offers a novel approach to identify driver genes in human cancer cells.