Fabrication of Biomimetic Bone Tissue Using Mesenchymal Stem Cell-Derived Three-Dimensional Constructs Incorporating Endothelial Cells

Jun-Ichi Sasaki, Masanori Hashimoto, Satoshi Yamaguchi, Yoshihiro Itoh, Itsumi Yoshimoto, Takuya Matsumoto, Satoshi Imazato
  • PLoS ONE, June 2015, Public Library of Science (PLoS)
  • DOI: 10.1371/journal.pone.0129266

Fabrication of Biomimetic Bone Tissue Using Mesenchymal Stem Cell

What is it about?

We hypothesized that incorporation of vascular endothelial cells would improve the cell survival rate and aid in the fabrication of biomimetic bone tissues in vitro. The purpose of this study was to assess the impact of endothelial cells combined with the MSC constructs (MSC/HUVEC constructs) during short- and long-term culture.

Why is it important?

These results demonstrate that highly biomimetic bone tissue can be fabricated in vitro by 3D MSC constructs incorporated with HUVECs.

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The following have contributed to this page: Dr Satoshi Yamaguchi