What is it about?
We evaluated the OpenArray platform for genetic testing to assess the genotype frequencies of nucleotide-polymorphisms associated with venous thrombosis, hyperhomocysteinemia and hereditary hemochromatosis among blood donors.
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Why is it important?
The OpenArray genotyping method was used to simultaneously detect seven different mutations in genes associated with a tendency to thrombosis and iron overload.
Perspectives
The OpenArray methodology showed good concordance of results when compared with other "gold-standard" methods to detect these gene mutations. Further studies may confirm the accurace of OpenArray method.
Dr Cesar de Almeida-Neto
Faculty of Medicine, University of São Paulo
Read the Original
This page is a summary of: Evaluation of a High Throughput Method for the Detection of Mutations Associated with Thrombosis and Hereditary Hemochromatosis in Brazilian Blood Donors, PLOS One, May 2015, PLOS,
DOI: 10.1371/journal.pone.0125460.
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