What is it about?
Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It is characterized by rapid expansion and the infiltration throughout healthy regions of the brain. GB cells interact with the cellular environment and healthy surrounding cells, mostly neurons and vessels and this cell-to-cell communication promotes GB growth and the degeneration of neurons.
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Why is it important?
Glioblastoma (GB) cells are resistant to current treatments and GB patients have a median survival of 15 months after diagnosis. GB cells that intercalate through the brain establish cell to cell contacts to communicate. We have discovered that these contacts are based on specific components known as synaptic proteins. We describe that GB cells also establish contacts with other GB cells (intratumoral) and these proteins are necessary for GB cells to expand and cause premature death.
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This page is a summary of: Synaptic components are required for glioblastoma progression in Drosophila, PLoS Genetics, July 2022, PLOS, DOI: 10.1371/journal.pgen.1010329.
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