What is it about?
The vagina and cervix (cervicovaginal microenvironment) contain a complex ecosystem that serves as an interface between human cells and bacteria that can be harmful (pathogens) or peacefully coexist (commensals). Dissecting these host-microbe interactions can be challenging, yet omics technologies provide a powerful tool to shed light on the structure of cervicovaginal microenvironment in health and disease. This paper employs a multi-omics approach and examines relationships between human papillomavirus, vaginal bacteria, and host defense and immune responses in women at different stages of cervical dysplasia or cancer.
Photo by Sarah Cervantes on Unsplash
Why is it important?
This work provides new mechanistic insights by linking specific metabolites and immune mediators with resident bacterial communities and cervical disease. We also learned that the metabolome was highly predictive of the local microenvironment, such as genital inflammation and the microbiome. Yet, the integration of multi-omics allowed us to yield mechanistic insights that would not have been possible by single omics approaches. Further improvement of multi-omics data integration methods will advance our ability to pinpoint constituents of the human microbiome contributing to health or disease in the female reproductive tract and beyond.
Read the Original
This page is a summary of: Multi-omics data integration reveals metabolome as the top predictor of the cervicovaginal microenvironment, PLoS Computational Biology, February 2022, PLOS, DOI: 10.1371/journal.pcbi.1009876.
You can read the full text:
The following have contributed to this page