What is it about?

Traditional Chinese Medicine (TCM) has been practicing unique and individualized methodologies for treating diseases, which have been developed over the course of many years of clinical experience. One of the fundamental concepts in TCM is Meridians. According to Meridian theory, the human body consists of 14 primary Meridian channels. Each Meridian is closely associated with one of the Chinese organs, such as the lungs, heart, and others. The Meridian theory is considered one of the most natural ways of treating diseases and has the potential to provide vital insights for modern disease treatment. However, the underlying mechanism of Meridians remains unknown.

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Why is it important?

Recent research using multiple machine learning methods has shown that structure-based fingerprints and ADME properties can predict the classification of Meridians. These findings provide evidence that the category of Meridians lies in their association with the molecular properties of herb compounds. The study has significant implications for the development of traditional Chinese medicine and modern drug discovery.


By leveraging multiple sources of data and AI technologies, we can gain a more comprehensive understanding of the Meridian system and its relationship to various aspects of human physiology. This approach may ultimately lead to new insights into the mechanisms of TCM and provide hints for the development of more effective treatments for a wide range of diseases.

Yinyin Wang

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This page is a summary of: Predicting Meridian in Chinese traditional medicine using machine learning approaches, PLoS Computational Biology, November 2019, PLOS, DOI: 10.1371/journal.pcbi.1007249.
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