What is it about?
Epiretinal membranes are thin sheets of tissue that develop pathologically in front of the retina and represent a serious threat to vision. Here we investigated one of its components, type-IV collagen, which is a protein of the extracellular matrix (i.e. the organic substance that is outside cells and fills the space between cells). Type-IV collagen is usually associated with basement membranes which, in turn, are always located in close proximity to cell membranes. Here we report that in epiretinal membranes type-IV collagen can be found far from cells, intermingled with other types of collagens.
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Why is it important?
The "ectopic" location of type-IV collagen is likely due to unknown interactions with other proteins of the extracellular matrix and it could contribute to the stiffness of the membrane and to its development
Perspectives
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This page is a summary of: The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes, Journal of Histochemistry & Cytochemistry, December 2019, SAGE Publications,
DOI: 10.1369/0022155419897258.
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