What is it about?
The glycoalkaloid Solamargine found to be effective to inhibit the growth of three different melanoma cell lines and its effect is proportionally related to malignancy in which it kills and causes necrosis to more malignant cell compared to primary or benign cells.
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Why is it important?
Solamargine was used to treat some non melanoma skin cancer and here we prove its effective action against metastatic melanoma cells in vitro, which holds the promise that it might work as a chemotherapy against melanoma after further investigation.
Perspectives
Looking for drugs to kills cancer cells but not normal cells is the dream of cancer biologists and the results we obtained with Solamargine against the melanoma cells are very promising and needs further deep investigation.
Dr Sirin A Adham
Sultan Qaboos University
Read the Original
This page is a summary of: Immunohistological Insight into the Correlation between Neuropilin-1 and Epithelial-Mesenchymal Transition Markers in Epithelial Ovarian Cancer, Journal of Histochemistry & Cytochemistry, May 2014, Journal of Histochemistry & Cytochemistry (The Histochemical Society),
DOI: 10.1369/0022155414538821.
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