What is it about?
Epiretinal membranes are thin sheets of tissue that develop pathologically in front of the retina and represent a serious threat to vision. Here we investigated one of its components, type-IV collagen, which is a protein of the extracellular matrix (i.e. the organic substance that is outside cells and fills the space between cells). Type-IV collagen is usually associated with basement membranes which, in turn, are always located in close proximity to cell membranes. Here we report that in epiretinal membranes type-IV collagen can be found far from cells, intermingled with other types of collagens.
Photo by Daniil Kuželev on Unsplash
Why is it important?
The "ectopic" location of type-IV collagen is likely due to unknown interactions with other proteins of the extracellular matrix and it could contribute to the stiffness of the membrane and to its development
Read the Original
This page is a summary of: The Peculiar Pattern of Type IV Collagen Deposition in Epiretinal Membranes, Journal of Histochemistry & Cytochemistry, December 2019, SAGE Publications, DOI: 10.1369/0022155419897258.
You can read the full text:
The following have contributed to this page