Distribution of Class I and II HLA Alleles in Turkish Children with Type 1 Diabetes Mellitus

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Type1Diabetes Mellitus (T1DM) is an autoimmune disease in which HLA gene polymorphisms vary according to region, race and ethnicity. Although there are many studies involving mostly DR-DQ haplotypes, there are fewer reports investigating the association of class I HLA-A, B and C alleles. The aim of the study was to investigate the distribution of HLA class I and II alleles in Turkish children with T1DM In this study, the most risky HLA alleles and haplotypes in Turkish children wtih T1DM were DR3-DQ2 and DRB1*03-DQB1*02, DRB1*04-DQB1*03, DRB1*01-DQB1*05, and the increased frequencies ofHLA-A2/A3, C7 / C4 and HLA B8 / 35 alleles were found in the HLA class I. These findings suggest that there is an increased frequency of HLA class II HLA DR3-DQ2 allele groups in Turkish children with T1DM, and the relationship between T1DM and HLA I class gene regions should be investigated because of the increased frequency of some HLA-A/B/C alleles (PDF) Tip 1 Diabetes Mellitus Tanılı Türk Çocuklarında Sınıf I ve Sınıf II HLA Allel Sıklığı. Available from: https://www.researchgate.net/publication/338025055_Tip_1_Diabetes_Mellitus_Tanili_Turk_Cocuklarinda_Sinif_I_ve_Sinif_II_HLA_Allel_Sikligi [accessed Feb 01 2020].

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