Construction of a per- and polyfluoroalkyl substances (PFAS) screening library
What is it about?
Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal toxicity data (e.g., perfluorooctanoic acid), whereas little toxicity and exposure information exists for much of the broader set of PFASs. Given that traditional approaches to generate toxicity information are resource intensive, new approach methods, including in vitro high-throughput toxicity (HTT) testing, are being employed to inform PFAS hazard characterization and further (in vivo) testing. The U.S. Environmental Protection Agency (EPA) and the National Toxicology Program (NTP) are collaborating to develop a risk-based approach for conducting PFAS toxicity testing to facilitate PFAS human health assessments. This article describes the construction of a PFAS screening library and the process by which a targeted subset of 75 PFASs were selected. Multiple factors were considered, including interest to the U.S. EPA, compounds within targeted categories, structural diversity, exposure considerations, procurability and testability, and availability of existing toxicity data.
Why is it important?
The article describes the construction of a PFAS screening library that will be used for high-throughput screening assay measurements to generate bioactivity data. It explains the process by which a targeted subset of 75 PFASs were selected from the large collection of PFAS chemicals registered on the CompTox Chemicals Dashboard at https://comptox.epa.gov/dashboard.
The following have contributed to this page: Dr Antony John Williams and Ronald N. Hines