What is it about?

This is to review of clinical presentation and natural history of neck keloids; to explore risk factors for development of large, very large and massive neck keloids; and to propose a clinical staging system that allows for categorization of keloid lesions by their size and grouping of keloid patients by the extent of their skin involvement.

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Why is it important?

1- Advancing our understanding of natural history and risk factors for development of large, very large and massive neck keloids can lead to improved treatment outcomes. 2- Clinical staging system for the categorization of keloid lesions, as well as grouping of keloid patients according to the extent of skin involvement is both fundamental for design and delivery of proper plan of care and an absolute necessity for methodical trial design and interpretation of the results thereof.

Perspectives

Knowing that keloid is a genetic disorder of wound-healing processes, it is counter-intuitive to resort to surgery as the mainstay of treatment. Surgical removal of keloid lesions is an intervention that is commonly practiced, defies the very basic principals of keloid formation. It is the injury to the skin of a genetically susceptible person that triggers keloidal wound healing response and formation of keloidal lesions. Surgical removal of neck or other keloids results in wounding of the skin and triggering of the same pathological wound-healing response that resulted in the formation of the keloid lesions that often leads to formation of a much larger keloid. Given the potential for greater harm from surgery, I propose non-surgical approach for treatment of all primary keloids. Also, attempts to properly categorize keloid lesions and to group keloid patients is hampered by the lack of a previously defined methodology. A clinical staging system is proposed to address the deficiency in grouping of keloid patients according to the size and extent of skin involvement with keloid lesions.

Michael H Tirgan
Rockefeller University

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This page is a summary of: Neck keloids: evaluation of risk factors and recommendation for keloid staging system, F1000Research, June 2016, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.9086.1.
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