Modeling the proteins in the Zika virus
What is it about?
This paper describes the construction of homology models for all the proteins in the Zika virus. Public software was used to generate these models which were evaluated with commercial and other tools. The Glycoprotein E model was used to generate a model of the complete virus. These various models are now publically accessible and can be used for docking etc.
Why is it important?
This is the first paper describing models for all the proteins in the Zika virus. 11 out of 15 appeared to be useful based on the model criteria described. This represents the starting point for future structure-based work to discover molecules that could bind to these proteins.
The following have contributed to this page: Dr Sean Ekins, Dr Rachelle J Bienstock, Dr Carolina Horta Andrade, and Dr Christopher Southan