What is it about?
This study was an experimental study using 30 Wistar male white rats. Subjects were randomly divided into 6 groups (n=5): (1) normal control group; (2) high fat diet control group; (3) high fat diet with simvastatin; (4-6) high fat diet with Zingiber montanum extracts 100, 200, and 400 mg/kg. After 4 weeks of treatment, blood was collected from all groups, and plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured.
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Why is it important?
Hypercholesterolemia, high cholesterol levels in the blood, can contribute to many forms of disease, most notably cardiovascular disease. Anti-hypercholesterolemic agents generally used for those conditions have several side effects for patients. Zingiber montanum, known locally as “bangle”, belongs to the family Zingiberaceae and is a potential plants for alternative anti-hypercholesterolemic agents. This plant, from East Kalimantan, is used in traditional medicine for health problems caused by high cholesterol levels.
Perspectives
It could be concluded that Z. montanum extracts have the potenial to reduce lipid profile level, which could be further developed as a natural source of the anti-hypercholesterolemic agents.
Swandari Paramita
Universitas Mulawarman
Read the Original
This page is a summary of: Anti-hypercholesterolemic effect of Zingiber montanum extract, F1000Research, November 2018, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.16417.1.
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