What is it about?
The spasmolytic activity of C. aeruginosa extracts was tested in separated organs of guinea pig trachea. Guinea pig was sacrificed and its trachea rings were suspended in L-shaped wire loops in organ baths containing the Krebs solution aerated with carbogen. Isometric contractions of tracheal rings were measured by the transducer coupled to the amplifier. The trachea rings were exposed to DMSO as negative control, aminophylline as positive control and C. aeruginosa extracts. The single concentration-relaxation curve was obtained in every preparation.
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Why is it important?
Asthma is a major health problem worldwide. Antiasthma drugs have side effects and can be expensive. It is important to develop antiasthma drugs from medicinal plants that have fewer side effects and are cheaper. One of the medicinal plants used for antiasthma treatment comes from Curcuma aeruginosa (Zingiberaceae family).
Perspectives
In this study, the examination of antiasthma effects of C. aeruginosa has been reported. The results of this study indicate that ethanol extract of C. aeruginosa has an antiasthma effect based on the tracheos- pasmolytic activity. Therefore, C. aeruginosa can be developed as a possible source of new antiasthma drugs.
Swandari Paramita
Universitas Mulawarman
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This page is a summary of: Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea, F1000Research, November 2018, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.16416.1.
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