What is it about?
Here we describe recent mutations in RAD51 that affect homologous recombination (HR). These mutations are mapped on the protein structure by which we can visualize the possible impacts on nucleoprotein filament formation and interaction with additional HR mediators.
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Why is it important?
In this review we describe the recently found mutations in RAD51 from genome sequencing (from tumors). RAD51 mutations are mostly only described in terms of filament structure and dynamics. The effects of mutations on the interactions with other mediators aren't described much. There are however, multiple HR mediators which are known to show interactions with RAD51. Here we want to stress this by showing mutations on the outside of the filament structure.
Perspectives
Knowledge of RAD51 mutations that might affect interactions with HR mediators, might lead to new insights and potential targets for small-molecule modulators/inhibitors that can direct/inhibit homologous recombination. Therefore these small molecules might lead to the development of novel anti-cancer agents for use in a personalized medicine strategy.
Nick van der Zon
Erasmus
Read the Original
This page is a summary of: Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy, F1000Research, September 2018, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.15650.1.
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