What is it about?
Areca nut is one of the plants with a risk of inducing oral squamous cell carcinoma; areca nut is believed to have high antioxidant properties. Due to the current interest in the apoptosis effects from areca nut for oral cancer treatment, we investigated the apoptosis and caspase-3 activities on the oral cancer cell lines: HSC-2 and HSC-3
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Why is it important?
Our findings show that areca nut induced a significant increase in late apoptosis of HSC-2 cells and mostly occurred over 48 hours. The study also found that in HSC-3, there were significant increases in early apoptosis percentage after 24 hours and late apoptosis in 48 hours. Caspase-3 activities increase after 24 and 48 hours of areca nut exposure in both cells. Thus, areca nut could be considered as a potential anticancer through its capability in inducing a caspase-dependent apoptosis.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long-standing collaborations. this article also lead our new perspective about the benefit of areca nut if we use it in a proper dose for cancer treatment.
Liza M Sari
Universitas Syiah Kuala
Read the Original
This page is a summary of: Areca nut extract demonstrated apoptosis-inducing mechanism by increased caspase-3 activities on oral squamous cell carcinoma, F1000Research, June 2018, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.14856.1.
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