What is it about?
Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development and we discuss BCR-derived signals on activated B cells that lead to an effective immune response.
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Why is it important?
BCR signaling strength and patterns affect B-cell selection during development. Furthermore, BCR signaling strength may affect antigen-induced B-cell activation, migration, and surface co-stimulator molecule expression levels.
Perspectives
There is still work to be done on how differential BCR signaling influences the differential development of B cells and how the various stages of antigen-induced T–B cell interactions affect further B-cell fate decisions.
Juan Carlos Yam-Puc
University of Birmingham
Read the Original
This page is a summary of: Role of B-cell receptors for B-cell development and antigen-induced differentiation, F1000Research, April 2018, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.13567.1.
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