What is it about?
Normal cellular function is determined by a very finely tuned balance between "activated" and "inactivated" proteins. This balance is mainly regulated by kinases, proteins that can "activate" proteins by adding phosphate groups. In this review we highlight the main and most current developments in methodologies used to identify the activation status of kinases.
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Why is it important?
By comparing kinase activation in normal versus cancerous (diseased) cells we can unveil new potential targets for cancer treatment. Thus it is important to have a good understanding of the current advances and limitations in kinome profiling methods.
Perspectives
Kinome profiling is a critical avenue in personalized medicine. With the hope that current methods for kinome profiling will soon become more friendly for high throughput platforms and that will be doable for smaller cell/tissue samples, I believe we are very close to offering individualized cancer therapies.
Maria Radu
Fox Chase Cancer Center
Read the Original
This page is a summary of: Recent advances in methods to assess the activity of the kinome, F1000Research, June 2017, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.10962.1.
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