What is it about?

We show for the first time how a drop of hydrogel can generate chronic nerve pain without surgery in a rat; and also how such persistent pain can be resolved with the targeted use of a natural hormone, erythropoietin.

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Why is it important?

In humans, chronic neural pain starts with tissue changes occurring at the site of a soft tissue injury, and rarely with surgical incisions. Yet all the current animal models used in drug research are created with incisions. Compared to other animal chronic neuropathic pain models, the GELTM model much more closely mimics the tissue changes, symptom development, and chronicity of human persistent pain. This model also mimics the human reaction to chronic opiate use, i.e., increasing pain over time. In contrast to all other animal models, the GELTM model is refined (3Rs) and humane.


Currently, many physicians and researchers assume, incorrectly, that neuropathic pain is incurable. The GELTM Model of neuropathic pain was reverse engineered from a very successful treatment protocol for patients with chronic pain determined to be caused by local tissue reactions involving the affected nerves. This scientific natural model demonstrates and explains how chronic pain starts, worsens, and persists, and most importantly, how such pain can be reversed.

Mary Hannaman
University of North Texas Health Sciences Center

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This page is a summary of: The refined biomimetic NeuroDigm GEL™ model of neuropathic pain in a mature rat, F1000Research, May 2017, Faculty of 1000, Ltd., DOI: 10.12688/f1000research.9544.2.
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