What is it about?

p-Chloroaniline is one of the banned aromatic amines in azo dyes. Tosylation contributes to separation of the isomeric chloroanilines by GC and differentiation of them by EI-MS. The mechanism of the MS-based differentiation was also investigated by density functional theory calculations.

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Why is it important?

This work provides a promising solution for simultaneous and accurate determination of isomeric chloroanilines.


I hope this article remind people that there is potential error in determination of isomeric compounds by GC or GC-MS. Derivatization might be a good solution for this problem.

Kezhi Jiang
Hangzhou Normal University

Read the Original

This page is a summary of: Isomeric differentiation of chloroanilines by gas chromatography-mass spectrometry in combination with tosylation, European Journal of Mass Spectrometry, January 2016, SAGE Publications, DOI: 10.1255/ejms.1426.
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