A new method for controlling particle size during melt granulation in a high shear mixer

What is it about?

This study explores a new method for controlling the size of tiny, round particles, called pellets. These pellets are made by mixing and melting powders in a machine called a high-shear mixer. These pellets are commonly used in pharmaceutical manufacturing. Rather than relying on trial and error or manual observation, the researchers use a measurement called specific energy consumption—essentially, the amount of energy the mixer consumes during production—to predict and control pellet size. They test different conditions, such as the amount of binder (a colloid-like substance) used, the size of the powder particles, and the speed of the mixer after melting begins. They find that the amount of energy consumed by the mixer closely correlated with the growth of pellet size. Therefore, by monitoring energy consumption, they could accurately control pellet size.

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Photo by Finn Mund on Unsplash

Photo by Finn Mund on Unsplash

Why is it important?

Particle size is crucial for pharmaceuticals: it influences their dissolution and absorption in the body. Uniform particle size ensures consistent dosage and quality. Traditional methods for particle size control lack precision and are difficult to automate. This new approach offers advantages: better control over the production process, improved consistency in product quality, and the potential for automation, saving time and reducing human error.

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