What is it about?
Pyruvate kinase M2 (PKM2) expression is associated with esophageal squamous cell carcinoma chemoresistance. PKM2 inhibition can restore cisplatin sensitivity by inactivating pentose phosphate pathway.
Featured Image
Why is it important?
PKM2 is a key glycolytic enzyme that regulates the Warburg effect and is necessary for tumor growth. However, its role in chemoresistance has not been fully elucidated.
Read the Original
This page is a summary of: Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway, Annals of Surgical Oncology, March 2015, Springer Science + Business Media,
DOI: 10.1245/s10434-015-4522-3.
You can read the full text:
Contributors
The following have contributed to this page
