What is it about?
Pyruvate kinase M2 (PKM2) expression is associated with esophageal squamous cell carcinoma chemoresistance. PKM2 inhibition can restore cisplatin sensitivity by inactivating pentose phosphate pathway.
Why is it important?
PKM2 is a key glycolytic enzyme that regulates the Warburg effect and is necessary for tumor growth. However, its role in chemoresistance has not been fully elucidated.
The following have contributed to this page: Shuichi Fukuda