Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway

  • Shuichi Fukuda, Hiroshi Miyata, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
  • Annals of Surgical Oncology, March 2015, Springer Science + Business Media
  • DOI: 10.1245/s10434-015-4522-3

What is it about?

Pyruvate kinase M2 (PKM2) expression is associated with esophageal squamous cell carcinoma chemoresistance. PKM2 inhibition can restore cisplatin sensitivity by inactivating pentose phosphate pathway.

Why is it important?

PKM2 is a key glycolytic enzyme that regulates the Warburg effect and is necessary for tumor growth. However, its role in chemoresistance has not been fully elucidated.

Read Publication

http://dx.doi.org/10.1245/s10434-015-4522-3

The following have contributed to this page: Shuichi Fukuda