Preclinical Evaluation of Ropivacaine in 2 Liposomal Modified Systems

What is it about?

We have shown for the first time that a new ropivacaine liposomal formulation was effective and safe for the tissues in animal models. The encapsulation of ropivacaine in a new kind of liposomes prepared with ionic-gradient was able to positively alter the pharmacokinetic profile of this local anesthetic, as demonstrated by lower plasma concentrations and reduced systemic exposure. This slow release probably evoked greater analgesic effect (~3 times), due to longer drug presence in the target effect site. Another important aspect is that the formulation was well tolerated at the injection site and in neuronal cell cultures. Thus, this formulation might be a novel tool for postoperative pain management.

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