What is it about?
Today, microRNAs are of great interest to scientists as possible novel means of diagnosing and treating diseases. Our study describes the specific microRNAs associated with WNT1 signaling in bone and show that a peculiar change in certain microRNAs is present circulating blood in result of impaired WNT1 signaling.
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Why is it important?
The current diagnostic and therapeutic means are insufficient in treating patients with WNT1 osteoporosis and these novel biomarkers could offer help in development of future diagnostic tools and target drugs. These findings also bring new information about the molecules regulating bone health and interacting with WNT1.
Perspectives
Our knowledge on the genetic and molecular mechanisms regulating bone health is still limited and studies on rare, monogenic diseases bring vital novel information. These will hopefully aid in development of new mechanisms to diagnose and treat not only rare inherited bone disorders but also common osteoporosis in the greater population as well.
Riikka Mäkitie
Klassillis-filologinen yhdistys ry
Read the Original
This page is a summary of: Altered MicroRNA Profile in Osteoporosis Caused by Impaired WNT Signaling, The Journal of Clinical Endocrinology & Metabolism, March 2018, Endocrine Society,
DOI: 10.1210/jc.2017-02585.
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