What is it about?
We used high-throughput RNA sequencing to investigate the transcriptome of pancreatic islets isolated from fetal sheep with intrauterine growth restriction.
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Why is it important?
We identify new genes that regulate proliferation and metabolism of the islets from growth restricted fetuses. In addition we show new processes that were previously undefined in islets from growth restricted fetuses. These include immune signaling, wnt signaling, adaptive hypoxia response, and proteasome.
Perspectives
The transcriptional changes identified provide a foundation for understanding programming mechanism that cause islets from growth restricted fetuses to fail later in life.
Sean Limesand
University of Arizona
Read the Original
This page is a summary of: RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets, Endocrinology, February 2017, Endocrine Society,
DOI: 10.1210/en.2016-1901.
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