What is it about?
We described an ultrasensitive ELISA assay that can detect mouse PRL in small fractions of whole blood, allowing longitudinal studies of PRL secretion profiles in freely moving mice. The combination of a sensitive PRL ELISA and administration of D2 receptor antagonist provide a unique opportunity to investigate the function and plasticity of the lactotroph axis in freely moving mice.
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Why is it important?
It is a novel technology used in mouse experiments on neuroendocrine research.
Perspectives
Chen lab developed techniques studying neuroendocrine hormone pulsatile profiles in mouse, here for PRL, but also for GH, LH, etc.
Professor Chen Chen
University of Queensland
Read the Original
This page is a summary of: Assessment of Lactotroph Axis Functionality in Mice: Longitudinal Monitoring of PRL Secretion by Ultrasensitive-ELISA, Endocrinology, May 2015, Endocrine Society,
DOI: 10.1210/en.2014-1571.
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