What is it about?
This is the 3rd paper in a series in which critical P-C parameters of several salt forms of a NCE are evaluated. Two methods using Numerical Analysis, involving seriousness of a problem and probability are compared to a logical method.
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Why is it important?
Numerical analysis can be a valuable tool when many salt forms (or methods) are compared and there are no clear advantages to permit a logical choice. Where each salt form or method considered has one or more serious flaws, and there is none without a flaw.
Perspectives
There are instances where a logical selection is problematic. For example, assume that each form tested has one or more serious problems. How does a formulator make a rational selection? By providing a mathematical numerical method with scoring, weighting, and potential for a problem a better decision might be made.
Dr. Frank A Chrzanowski
ExpertPharma, LLC
Read the Original
This page is a summary of: Preformulation Considerations for Controlled Release Dosage Forms: Part III. Candidate Form Selection Using Numerical Weighting and Scoring, AAPS PharmSciTech, May 2008, American Association of Pharmaceutical Scientists (AAPS),
DOI: 10.1208/s12249-008-9069-1.
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