What is it about?
Part 2 gives examples of the P-C properties from several NCEs that were in the development phase. Examples of solubility vs pH, Stability/kinetics vs pH, polymorphs and hydrates, excipient compatibility and others.
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Why is it important?
The examples are valuable in providing methods of resolution, citing important P-C Characteristics that should be investigated. Th paper title includes CONTROLLED RELEASE. However, the manuscript could just as well been entitled as IMMEDIATE RELEASE. The manuscript was developed from a previous presentation that dealt with IMMEDIATE RELEASE dosage form development.
Perspectives
The manuscript had a lot of attention and several citations. It was well received when it was presented at a Controlled Release Symposium and before that the material was well received in a class room of undergraduate Pharmacy students and an audience where the Immediate Release aspects were presented.
Dr. Frank A Chrzanowski
ExpertPharma, LLC
Read the Original
This page is a summary of: Preformulation Considerations for Controlled Release Dosage Forms: Part II—Selected Candidate Support, AAPS PharmSciTech, March 2008, American Association of Pharmaceutical Scientists (AAPS),
DOI: 10.1208/s12249-008-9067-3.
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