Acidification of the intimal fluid: the perfect storm for atherogenesis

Katariina Öörni, Kristiina Rajamäki, Su Duy Nguyen, Katariina Lähdesmäki, Riia Plihtari, Miriam Lee-Rueckert, Petri T. Kovanen
  • The Journal of Lipid Research, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB)
  • DOI: 10.1194/jlr.r050252

Atherosclerotic lesions are acidic - here's an explanation why

What is it about?

Atherosclerotic lesions have areas that are acidic. We and others have been examining how this influences the atherosclerotic lesions. It actually seems that acidic pH increases lipid accumulation in the lesions, increases inflammation, and decreases the good effects of HDL particles. This review article collected all the information in one article.

Why is it important?

It seems that acidic pH can make atherosclerosis worse. It is important to know the conditions in the lesions and how they influence progression of the disease. The lesions that are particularly acidic may be the ones that cause symptoms - therefore it would be important to know how and why and what can we do to prevent this.

Perspectives

Dr Katariina Öörni
Wihuri Research Institute

We have been working on the effects of acidity on atherosclerosis for some time - some of these articles are linked below - and wanted to collect all the information from us and others into a review article.

Read Publication

http://dx.doi.org/10.1194/jlr.r050252

The following have contributed to this page: Dr Katariina Öörni