What is it about?
Both HCC and cirrhosis groups showed decrease in Firmicutes, F/B ratio, A. mucinophilia, and F. prausnitzii compared to the control group. However, the HCC group only showed statistically significant increase in Bacteroides and Lactobacilli, and decrease of Prevotella relative abundance and P/B ratio compared to both cirrhosis and control groups. As regard the relation between the gut microbiome and stages of HCC, BCLC stage D showed significantly the lowest relative abundance of Ruminococcus.
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Why is it important?
This may help in the development of new approaches for treatment and prevention of HCC by modulating the gut microbiome.
Perspectives
Patients with HCV-related cirrhosis and HCC exhibit microbial dysbiosis; altered microbial relative abundance and diversity with HCC patients showing higher proinflammatory bacteria compared to cirrhotics.
Abdurrahman Najeeb
Alexandria University
Read the Original
This page is a summary of: Gut microbiome in cirrhotic hepatitis C virus patients with and without hepatocellular carcinoma, Egyptian Liver Journal, September 2021, Springer Science + Business Media,
DOI: 10.1186/s43066-021-00147-y.
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