What is it about?
The IKZF1 gene encodes the Ikaros transcription factor, which is essential for normal lymphocyte development and differentiation. Genetic variations in IKZF1, particularly the SNPs rs4132601 and rs11978267, have been implicated in altering gene function and increasing susceptibility to ALL, a common childhood cancer characterized by the malignant proliferation of lymphoid progenitor cells. However, individual studies examining the association between these SNPs and ALL risk have produced varying results due to limited sample sizes and population heterogeneity.
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Photo by National Cancer Institute on Unsplash
Why is it important?
Understanding the role of IKZF1 SNPs in ALL susceptibility is vital because IKZF1 is a key regulator of lymphocyte development, and its dysfunction can drive malignant transformation in hematopoietic cells. Acute lymphoblastic leukemia is the most common cancer in children, and identifying genetic risk factors like rs4132601 and rs11978267 helps explain individual differences in disease onset and progression.
Perspectives
IKZF1 SNPs influence gene function critical for lymphocyte development, contributing to genetic susceptibility to ALL. Identifying these SNPs aids in early risk assessment and personalized treatment strategies for patients with ALL. Comprehensive meta-analyses resolve inconsistencies across studies, enhancing understanding of ALL pathogenesis and guiding future therapeutic targets.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis, Journal of the Egyptian National Cancer Institute, April 2025, Springer Science + Business Media,
DOI: 10.1186/s43046-025-00274-2.
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