What is it about?

This study was aimed to identify and measure the level of gene expressions that are responsible for coding to killer toxins in 31 different type strains with antibacterial activity and cytotoxicity of two killer toxins.

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Why is it important?

The results of M28, M1, and M2 gene expression showed that Wickerhamomyces anomalus and Torulaspora delbrueckii had the highest expression compared to the remaining 29 isolates that appeared in less gene expression. The high value of gene expression was compared with the lowest value to determine the fold change for Wickerhamomyces anomalus. The fold change values for the genes M28, M1, and M2 were 66.913, 2011.714, and 47314.69, respectively, while the fold change of Torulaspora delbrueckii for the genes M28, M1, and M2 were 8.135, 938.497, and 3541,146, respectively. These results clarified the fold change for all genes. The highest fold change value occurred in Wickerhamomyces anomalus compared to Torulaspora delbrueckii. This means that the Wickerhamomyces anomalus has a high ability in production amount compared with Torulaspora delbrueckii.

Perspectives

The two typical strains Torulaspora delbrueckii and Wickerhamomyces anomalus showed the highest level of gene expression for the three killer toxins. All isolates of the non-Saccharomyces cerevisiae that tested for gene expression of the three toxins gave uneven positive results indicating the presence of mycovirus in all the examined isolates. Also, two purification killer toxins exhibited antibacterial activity with no toxicity against blood cells.

Dr. Mohammed Hussein Minati

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This page is a summary of: A new report on gene expression of three killer toxin genes with antimicrobial activity of two killer toxins in Iraq, Bulletin of the National Research Centre, September 2020, Springer Science + Business Media,
DOI: 10.1186/s42269-020-00418-5.
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