yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese

What is it about?

Rats were fed with high-fat (HF) diet for 4-weeks to induce obesity, and then yam dioscorin was intervened concurrent with HF diet to observe the changes of blood pressure and impaired glucose tolerances.

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Why is it important?

There were no significant difference in body weights, feed intakes, feed conversion, and weights of adipose tissues of obese rats in groups of HF and (HF diet + dio50). However, the systolic blood pressures in obese rats of 2-, 3- and 4-week dioscorin interventions were showed significantly lower (P < 0.05) compared to the HF group. The dioscorin intervention (HF+ dio50) was showed significantly different (P < 0.05) and improved the impaired glucose tolerances compared to HF group in obese rats by the oral glucose tolerance tests.