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Why is it important?
Identify a natural occurring agent that can suppress GRP78 translation, thereby depriving the cancer cells of this critical pro-survival protein and depriving the SARS-CoV-2 virus the co-receptor for entry into the host cell and production of viral proteins.
Perspectives
Further clinical development of oleandrin will benefit patients battling cancer and patients afflicted with COVID-19.
Amy Lee
University of Southern California
Read the Original
This page is a summary of: Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19, Cell & Bioscience, September 2024, Springer Science + Business Media,
DOI: 10.1186/s13578-024-01297-3.
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