What is it about?
Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) is only 12%, the efficiency of the procedure needs to be improved before clinical implementation is possible. Co-transplantation of mesenchymal stem cells (MSCs) might increase colonization efficiency of SSCs by restoring the SSC niche after gonadotoxic treatment.
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Why is it important?
Advanced cancer treatments have resulted in more than 80% survival rate of childhood cancer patients. However, a childhood cancer survivor study reported that 46% of these patients would become infertile, while 18% of their siblings will experience fertility problems in adulthood. As these boys lack active spermatogenesis at the time of cancer diagnosis, they cannot benefit from sperm freezing. Testicular tissue banking in combination with spermatogonial stem cell transplantation (SSCT) has been proposed as a possible fertility preservation strategy for these patients.
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This page is a summary of: Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice, Stem Cell Research & Therapy, November 2018, Springer Science + Business Media,
DOI: 10.1186/s13287-018-1065-0.
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