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Authors determined that overexpression of protein disulfide isomerase conferred a survival advantage in vitro and in vivo to human myoblasts injected into murine dystrophic muscle and to endothelial cells administered upon hindlimb ischemia damage, improving the therapeutic outcome of the cell therapy treatment. Overexpression of protein disulfide isomerase may protect transplanted cells from hypoxia and other possibly occurring endoplasmic reticulum stresses, and enhance their regenerative properties.
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This page is a summary of: Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases, Stem Cell Research & Therapy, September 2018, Springer Science + Business Media,
DOI: 10.1186/s13287-018-0986-y.
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Stem Cell Research & Therapy Open Access
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Muscle Cell News
Muscle Cells News Volume 3,.33. Oct. 1 2018
Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Int J Mol Sci (2017); 18(10):2087. doi: 10.3390/ijms18102087.
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