What is it about?
Chromatin is usually stabilized when the linker histone H1 contacts the core nucleosome and the DNA linking adjacent nucleosomes. We show here that such stabilization is conferred by interaction with the HMGB protein HMO1.
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Why is it important?
The previously characterized yeast linker histone, Hho1p, has been implicated in functions other than the general stabilization of chromatin typically ascribed to H1. This work reports that a separate protein appears to be responsible for such stabilizing functions.
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This page is a summary of: The high mobility group protein HMO1 functions as a linker histone in yeast, Epigenetics & Chromatin, March 2016, Springer Science + Business Media,
DOI: 10.1186/s13072-016-0062-8.
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