What is it about?
Preserving the buffering capacity of cerebral blood flow may represent a relevant physiological target for the refinement of multimodal neuromonitoring strategies.
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Why is it important?
It challenges the traditional interpretation of PbtO₂ under hyperoxemia, proposing a physiologically grounded framework that links oxygen dynamics to hemoglobin states and cerebral metabolism.
Perspectives
This work encourages a paradigm shift in brain oxygen monitoring, integrating biochemical hemoglobin behavior into multimodal neuromonitoring to improve interpretation, precision, and clinical decision-making.
GURGEN HARUTYUNYAN
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This page is a summary of: Rethinking PbtO₂ responses to hyperoxemia: laying the groundwork for a new approach to multimodal neuromonitoring, Critical Care, October 2025, Springer Science + Business Media,
DOI: 10.1186/s13054-025-05502-8.
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