A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

What is it about?

Curcumin is considered a chemopreventive molecule with anti-oxidant, anti-apoptotic and anti-inflammatory properties targeting both NRF2 and p53 and have anti-tumor activity. The oncosuppressor p53 plays a key role in cell growth and apoptosis in response to various stress signals while NRF2 is the main regulator of cellular antioxidant response. In this study, the authors evaluate a novel curcumin compound across various cancer cell lines. They demonstrate that curcumin-induced NRF2 expression promotes cell survival, regardless of whether the cells undergo mutant p53 downregulation or wild-type p53 activation.

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Photo by Lucy Turner on Unsplash

Photo by Lucy Turner on Unsplash