p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

What is it about?

This paper explores how high glucose conditions impact p53 activity. In high glucose, p53 promotes DRAM expression, leading to increased autophagy, and reduced apoptosis. DRAM knockdown or autophagy inhibition restores apoptotic activity and PUMA transcription in high glucose conditions. These findings provide critical insights into how hyperglycemia may modulate the efficacy of chemotherapy in diabetic cancer patients.

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Photo by Elena Leya on Unsplash

Photo by Elena Leya on Unsplash