cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis

What is it about?

cMYC regulates approximately 15% of human genes and is involved in up to 20% of all human cancers. The aims of the current study were to clarify patterns and intensities of cMYC protein expression in follicular cell-derived thyroid carcinomas, to correlate cMYC with BRAFV600E expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas.

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Why is it important?

Our study suggests that nuclear overexpression of cMYC correlates with tumorigenesis / dedifferentiation in follicular cell derived thyroid carcinomas, a concept that has not been shown before on whole tissue sections.