BAFF blockade in experimental autoimmune encephalomyelitis reduces inflammation in the meninges and synaptic and neuronal loss in adjacent brain regions

What is it about?

The research paper discusses the effects of BAFF (B cell-activating factor) blockade in an experimental autoimmune encephalomyelitis (EAE) model, which is a widely used animal model to study multiple sclerosis (MS). The study focuses on how BAFF blockade reduces inflammation in the meninges (the protective membranes covering the brain) and protects against synaptic and neuronal loss. We used anti-BAFF antibody treatment in mice and found that it led to a decrease in B cells, T cells, and myeloid cells in the meninges, as well as preserved neuronal and synaptic densities in the hippocampus and cortex. This suggests that BAFF blockade could be a potential therapeutic strategy for MS. The paper also includes detailed methods and results, such as immunohistochemistry and MRI imaging, to support their findings.

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