Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays

  • Christina D. Martinez-Brokaw, Joshua B. Radke, Joshua G. Pierce, Alexandra Ehlers, Sean Ekins, Kelly E. Wood, Jon Maakestad, Jacqueline A. Rymer, Kenichi Tamama, Matthew D. Krasowski
  • BMC Clinical Pathology, February 2019, Springer Science + Business Media
  • DOI: 10.1186/s12907-019-0084-9

Investigating drug of abuse immunoassay cross reactivity of vilazodone and metabolites.

What is it about?

We used computational and experimental approaches to assess potential cross reactivity of the anti depressant vilazodone. We tested cross reactivity and none could be observed.

Why is it important?

It may suggest that there are other metabolites in toddlers which will require further assessment.

Perspectives

Dr Sean Ekins
Collaborations in Chemistry

A nice collaboration between synthesis of the vilazodone metabolite, computational and in vitro assessment of ccross reactivity.

Read Publication

http://dx.doi.org/10.1186/s12907-019-0084-9

The following have contributed to this page: Dr Sean Ekins