Bariatric surgery can induce diabetes mellitus remission

What is it about?

Prediabetes is a dysglycemic state that confers a high risk for overt type 2 diabetes (T2D), and is thought by most authors to be a precursor of T2D. People with prediabetes are at risk of the same microvascular and macrovascular complications (including cardiovascular risk) as patients with diabetes, although the risk is lower. A lot of uncertainty regarding diagnostic criteria and treatment options and targets remain to be established. The need for remission of prediabetes and for prevention of progression from prediabetes to T2D seems logical and has been largely studied through lifestyle modification and glucose-lowering drug approaches. The combined results show that diabetes incidence can be greatly reduced with these approaches. Little is known regarding the effect of bariatric surgery (BS) on the remission of prediabetes. BS is a highly effective treatment for obesity, which is associated with a significant cardiometabolic improvement, and has been proven to reduce cardiovascular risk both in patients with diabetes and prediabetes. There is firm evidence regarding diabetes remission after BS and glucose metabolism improvement. Our group has previously studied predictors of diabetes remission after BS and concluded that patients age, preoperative glycated haemoglobin and preoperative beta cell are useful for predicting diabetes remission. In addition, it was shown that short T2D duration and good glycaemic control before BS were associated with longlasting diabetes remission. We showed a high prediabetes remission rate after bariatric surgery. The remission rate decreases over the follow-up period, although most of the patients maintain the normoglycemia. Prediabetes remission seems to be more significant in patients who had undergone GS, in male and in younger patients.

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Why is it important?

Preventing diabetes we can prevent diabetic complications

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